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United States of America Patent and Trademark Office. Granted Patents (USPTO) >
5762939
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Patent Details
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Inventor
Gale Eugene Smith { }
Franklin Volvovitz { }
Bethanie Eident Wilkinson { }
Craig Stanway Hackett { }
Assignee
Mg-Pmc, LLC { }
Attorney
Curtis Morris & Safford PC
Thomas J Kowalski
IPC Codes
A61K 39/145
C07K 14/11
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Patent Office: United States of America Patent and Trademark Office. Granted Patents (USPTO) 
Title: Method for producing influenza hemagglutinin multivalent vaccines usingbaculovirus
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Application No: 8/120607
Publication No: 5762939
Application Date: 1993-09-13
Publication Date: 1998-06-09
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Abstract
A method of preparing a recombinant influenza vaccine using DNA technology is provided. The resulting vaccine is a trivalent influenza vaccine based on a mixture of recombinant hemagglutinin antigens cloned from influenza viruses having epidemic potential. The recombinant hemagglutinin antigens are full length, uncleaved (HA0), glycoproteins produced from baculovirus expression vectors in cultured insect cells and purified under non-denaturing conditions. The process for cloning influenza hemagglutinin genes from influenza A and B viruses uses specially designed oligonucleotide probes and PCR. The cloned HA genes are then modified by deletion of the natural hydrophobic signal peptide sequences and replacing them with a new baculovirus signal peptide. A general approach for the efficient extraction and purification of recombinant HA protein produced in insect cells is also disclosed which can be adapted for the purification of rHA proteins from A sub-types and B type influenza viruses. The procedure produces substantially pure rHA which is a biologically active hemagglutinin, non-denatured, and suitable as a component in human or other animal influenza vaccines.
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US5762939 at USPTO
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Referenced by : 15 patent(s) worldwide
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Inventor: De-chu C Tang { }; Donald H Marks { }; David T Curiel { }; Zhongkai Shi { }
Assignee: The UAB Research Foundation { }
Attorney: Frommer Lawrence & Haug LLP - William S Frommer; Thomas J Kowalski
Title: Noninvasive genetic immunization, expression products therefrom, and uses thereof
Patent Office: United States of America Patent and Trademark Office. Granted Patents (USPTO) Document Number: US6716823
Referenced by: 3
 
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Inventor: Alvin H Schmaier { }; Ahmed A K Hasan { }
Assignee: Thromgen, Inc { }; Regents of the University of Michigan { }
Attorney: Venable - Keith G Haddaway; Julie A Petruzzelli
Title: Peptide analogs as selective inhibitors of thrombin activation of protease activated receptor 1
Patent Office: United States of America Patent and Trademark Office. Granted Patents (USPTO) Document Number: US6544750
Referenced by: 3
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Inventor: Kyoung-Jin Yoon { }; Vickie Cooper { }
Assignee: Iowa State University Research Foundation, Inc { }
Attorney: Barnes & Thornburg LLP - Sendil K Devadas
Title: Canine influenza virus and related compositions and methods of use
Patent Office: United States of America Patent and Trademark Office. Granted Patents (USPTO) Document Number: US7468187
Referenced by: 1
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Inventor: Ho Sung Cho { }; Thomas O Daniel { }; Anna-Maria Hays { }; Troy E Wilson { }; David C Litzinger { }; Roberto Mariani { }; Bruce E Kimmel { }; William M Keefe { }
Assignee: Ambrx, Inc { }
Attorney: nullJohn W Wallen, III; Kristin S Eaton
Title: Biosynthetic polypeptides utilizing non-naturally encoded amino acids
Patent Office: United States of America Patent and Trademark Office. Granted Patents (USPTO) Document Number: US7638299
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Inventor: Feng Tian { }
Assignee: Ambrx, Inc { }
Attorney: nullJohn W Wallen, III; Kristin S Eaton
Title: Compositions of tRNA and uses thereof
Patent Office: United States of America Patent and Trademark Office. Granted Patents (USPTO) Document Number: US7632823
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Inventor: Ho Sung Cho { }; Thomas O Daniel { }; Troy E Wilson { }; Thomas P Cujec { }; Feng Tian { }; Anna-Maria Hays { }; Bruce E Kimmel { }; Lillian Ho { }
Assignee: Ambrx, Inc { }
Attorney: nullJohn W Wallen, III; Kristin S Eaton
Title: Antigen-binding polypeptides and their uses
Patent Office: United States of America Patent and Trademark Office. Granted Patents (USPTO) Document Number: US7632924
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Inventor: John Jefferson Arnold { }; Chun-Ming Huang { }; Elias Meezan { }; Dennis J Pillion { }; De-Chu C Tang { }
Assignee: The UAB Research Foundation { }
Title: Alkyl-glycoside enhanced vaccination
Patent Office: United States of America Patent and Trademark Office. Granted Patents (USPTO) Document Number: US7524510
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Inventor: Gregory V Williams { }; Kenneth Hughes { }
Assignee: Microbix Biosystems, Inc { }
Title: Virus production
Patent Office: United States of America Patent and Trademark Office. Granted Patents (USPTO) Document Number: US7270990
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Inventor: Alessandra D'Azzo { }; Erik Jacobus Bonten { }
Assignee: St Jude Children's Research Hospital { }
Attorney: nullJ Scott Elmer
Title: Targeting proteins to cells expressing mannose receptors via expression in insect cells
Patent Office: United States of America Patent and Trademark Office. Granted Patents (USPTO) Document Number: US7232670
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Inventor: De-chu Tang { }; Donald H Marks { }; David T Curiel { }; Zhongkai Shi { }
Assignee: The UAB Research Foundation { }
Attorney: Frommer Lawrence & Haug LLP - William S Frommer; Thomas J Kowalski
Title: Vaccination by topical application of genetic vectors
Patent Office: United States of America Patent and Trademark Office. Granted Patents (USPTO) Document Number: US6706693
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Reference cited : 4 patent(s) worldwide
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